Bile Acid Analogs with Anti-Germination Activities for Prophylaxis of <i>Clostridioides difficile</i> Infection Alter Bile Acid Homeostasis in the Enterohepatic Cycle

We previously reported that two bile acid (BA) analogs, CamSA and CA-Quin, demonstrate potent anti-germination activity against <i>Clostridioides difficile</i> (<i>C. difficile</i>) spores, protecting rodents from <i>C. difficile</i> infections. Here, we further evaluated the impact of these analogs...

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Autori principali:	Nivisa Vakeesan, Efren Heredia, Chandler Hassan, Yang Jiang, Shiv Sharma, Lianyong Su, Huiping Zhou, Steven Firestine, Ernesto Abel-Santos, Wanqing Liu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2025-12-01
Serie:	Biomolecules
Soggetti:	<i>C. difficile</i> bile acid enterohepatic circulation gut microbiota transcriptome
Accesso online:	https://www.mdpi.com/2218-273X/15/12/1672
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