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Targeting cellular senescence in metabolic disease

Cellular senescence is a cell fate involving cell cycle arrest, resistance against apoptosis, and the development of a secretome that can be pro-inflammatory. In aging and obesity, senescent cells accumulate in many tissues, including adipose tissue, brain, kidney, pancreas, and liver. These senesce...

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Bibliografiska uppgifter
Huvudupphov: Allyson K. Palmer, Tamar Tchkonia, James L. Kirkland
Materialtyp: Artigo
Språk:Inglês
Utgiven: Elsevier 2022-12-01
Serie:Molecular Metabolism
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Länkar:http://www.sciencedirect.com/science/article/pii/S2212877822001703
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