ACOX2 destabilizes the MRE11-RAD50-NBS1 complex and boosts anticancer immunity via the cGAS-STING pathway in clear cell renal cell carcinoma

Abstract The rapid development of ICI-based immunotherapy has ushered in a promising era for clear cell renal cell carcinoma (ccRCC). However, durable clinical responses remain limited to a subset of patients. Therefore, identifying novel predictive biomarkers and developing effective combination im...

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Detalhes bibliográficos

Principais autores:	Shiqi Ye, Wenhao Xu, Zheqi Chen, Chuanying Zhu, Qintao Ge, Jiahe Lu, Kun Chang, Xi Tian, Aihetaimujiang Anwaier, Shuxuan Zhu, Siqi Zhou, Wei Zhang, Yue Wang, Jianyuan Zhao, Lingling Li, Yan Shi, Tingting Cai, Danfeng Xu, Xiangyu Zhou, Dingwei Ye, Hailiang Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-10-01
coleção:	Molecular Cancer
Assuntos:	ACOX2 MRE11-RAD50-NBS1 complex Homologous recombination repair cGAS-STING pathway Tertiary lymphoid structures
Acesso em linha:	https://doi.org/10.1186/s12943-025-02420-9
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