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Increased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samples

<p>Abstract</p> <p>Background</p> <p>Duplication of chromosome 15q11-q13 (dup15q) accounts for approximately 3% of autism cases. Chromosome 15q11-q13 contains imprinted genes necessary for normal mammalian neurodevelopment controlled by a differentially methylated imprinting center (imprinting cente...

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Main Authors: Scoles Haley A, Urraca Nora, Chadwick Samuel W, Reiter Lawrence T, LaSalle Janine M
Format: Artigo
Language:Inglês
Published: BMC 2011-12-01
Series:Molecular Autism
Subjects:
autism
imprinting
copy number variation
15q
duplication
methylation
epigenetic
Online Access:http://www.molecularautism.com/content/2/1/19
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