The Complex Effects of PKM2 and PKM2:IP₃R Disruption on Intracellular Ca²⁺ Handling and Cellular Functions

Pyruvate kinase M (PKM) 2 was described to interact with the inositol 1,4,5-trisphosphate (IP₃) receptor (IP₃R) and suppress its activity. To further investigate the physiological importance of the PKM2:IP₃R interaction, we developed and characterized HeLa PKM2 knock...

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Bibliografische Detailangaben

Hauptverfasser:	Fernanda O. Lemos, Ian de Ridder, Martin D. Bootman, Geert Bultynck, Jan B. Parys
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2023-10-01
Schriftenreihe:	Cells
Schlagworte:	pyruvate kinase M2 IP<sub>3</sub> receptor intracellular Ca<sup>2+</sup> signaling apoptosis ER-mitochondria contact sites
Online-Zugang:	https://www.mdpi.com/2073-4409/12/21/2527
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