Targeting nitrative stress for attenuating cisplatin-induced downregulation of cochlear LIM domain only 4 and ototoxicity

Cisplatin-induced ototoxicity remains a primary dose-limiting adverse effect of this highly effective anticancer drug. The clinical utility of cisplatin could be enhanced if the signaling pathways that regulate the toxic side-effects are delineated. In previous studies, we reported cisplatin-induced...

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Autors principals:	Samson Jamesdaniel, Rajamani Rathinam, William L. Neumann
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2016-12-01
Col·lecció:	Redox Biology
Matèries:	Cisplatin Ototoxicity Protein nitration LMO4 Cochlea Hearing loss
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2213231716302270
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