Antisense oligonucleotides targeting the SARS-CoV-2 nucleocapsid gene decrease viral titers in hamsters

SARS-CoV-2 is a positive, single-stranded RNA coronavirus responsible for the COVID-19 pandemic. The emergence of new variants and the limited efficacy of current antivirals demonstrate the need for novel therapeutic strategies. Here, we present the design, screening, and evaluation of antisense oli...

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Autors principals:	Christopher Fitzpatrick, Nicolas Meunier, Sophie Lepoder, Sophie Dhorne-Pollet, Bruno Da Costa, Bernard Klonjkowki, Jean-François Eléouët, Verónica A. Burzio, Bernard Delmas, Eric Barrey
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-09-01
Col·lecció:	Molecular Therapy: Nucleic Acids
Matèries:	MT: Oligonucleotides Therapies and Applications antiviral RNA therapy COVID-19 nucleocapsid
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2162253125001660
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