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NONO interacts with nuclear PKM2 and directs histone H3 phosphorylation to promote triple-negative breast cancer metastasis

Abstract Background Emerging evidence has revealed that PKM2 has oncogenic functions independent of its canonical pyruvate kinase activity, serving as a protein kinase that regulates gene expression. However, the mechanism by which PKM2, as a histone kinase, regulates the transcription of genes invo...

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Päätekijät: Qixiang Li, Hongfei Ci, Pengpeng Zhao, Dongjun Yang, Yi Zou, Panhai Chen, Dongliang Wu, Wenbing Shangguan, Wenyang Li, Xingjun Meng, Mengying Xing, Yuzhong Chen, Ming Zhang, Bing Chen, Lingdong Kong, Ke Zen, David C. S. Huang, Zhi-Wei Jiang, Quan Zhao
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BMC 2025-03-01
Sarja:Journal of Experimental & Clinical Cancer Research
Aiheet:
Transcription
Epigenomics
H3T11ph
NONO
PKM2
Triple-negative breast cancer
Linkit:https://doi.org/10.1186/s13046-025-03343-5
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