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Involvement of CD40-CD40L and ICOS-ICOSL in the development of chronic rhinosinusitis by targeting eosinophils

BackgroundChronic rhinosinusitis (CRS), whose prevalence and pathogenesis are age-related, is characterized by nasal tissue eosinophil infiltration. CD40-CD40 ligand (CD40L) pathway involves in the eosinophil-mediated inflammation, and inducible co-stimulator (ICOS)–ICOS ligand (ICOSL) signal can st...

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Bibliografiske detaljer
Principais autores: Aina Zhou, Chenxi Shi, Yuhui Fan, Yushuang Zheng, Jue Wang, Zhichen Liu, Huanxia Xie, Jisheng Liu, Qingqing Jiao
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-06-01
Serier:Frontiers in Immunology
Fag:
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1171308/full
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