Mutations of Cx43 that affect B cell spreading in response to BCR signaling

The gap junction (GJ) protein connexin 43 (Cx43) is both necessary and sufficient for B cell receptor (BCR)-mediated cell spreading. To address how Cx43 mediates this effect, we blocked its function genetically, by expressing mutants of Cx43, and pharmacologically, by using chemical inhibitors. Whil...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Letitia Falk, May Dang-Lawson, José Luis Vega, Farnaz Pournia, Kate Choi, Caren Jang, Christian C. Naus, Linda Matsuuchi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	The Company of Biologists 2014-07-01
Colecção:	Biology Open
Assuntos:	B cell B cell receptor BCR Cx43 Connexin 43 Hemichannel Gap junction protein
Acesso em linha:	http://bio.biologists.org/content/3/3/185
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!