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A Three-Monoclonal Antibody Combination Potently Neutralizes BoNT/G Toxin in Mice

Equine-derived antitoxin (BAT<sup>®</sup>) is the only treatment for botulism from botulinum neurotoxin serotype G (BoNT/G). BAT<sup>®</sup> is a foreign protein with potentially severe adverse effects and is not renewable. To develop a safe, more potent, and renewable antitoxin, humanized monoclona...

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Principais autores: Yongfeng Fan, Jianlong Lou, Christina C. Tam, Weihua Wen, Fraser Conrad, Priscila Leal da Silva Alves, Luisa W. Cheng, Consuelo Garcia-Rodriguez, Shauna Farr-Jones, James D. Marks
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-04-01
Colecção:Toxins
Assuntos:
botulinum neurotoxin
oligoclonal antibodies
serotype G botulism
recombinant antibodies
antibody engineering
mouse neutralization assay
Acesso em linha:https://www.mdpi.com/2072-6651/15/5/316
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