Serial analysis of ESR1 mutations in cell-free DNA from hormone receptor-positive, HER2-negative metastatic breast cancer during palliative endocrine therapy

BackgroundActivating mutations in ESR1 gene are a known mechanism of endocrine resistance. We analyzed ESR1 mutations in cell-free DNA (cfDNA) from serially collected blood from hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer patients to investig...

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मुख्य लेखकों:	Soo Yeon Baek, Meehyang Hong, Seungah Lee, Seulgi Joo, JungPil Jang, Chinkoo Jung, Hyein Lee, Tae-Kyung Yoo, Il Yong Chung, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Hyehyun Jeong, Jae Ho Jeong, Jin-Hee Ahn, Kyung Hae Jung, Sung-Bae Kim, Hee Jin Lee, Gyungyub Gong, Sae Byul Lee, Jisun Kim
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Frontiers Media S.A. 2026-01-01
श्रृंखला:	Frontiers in Oncology
विषय:	breast cancer cell-free DNA circulating tumor DNA endocrine therapy ESR1 mutation
ऑनलाइन पहुंच:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1709317/full
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