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Associations of cerebrospinal fluid measures of synaptic function with white matter microstructure and cognition in older adults

IntroductionLower levels of several synaptic proteins in cerebrospinal fluid (CSF) have been associated with greater cognitive decline among older adults, but there is limited understanding of their associations with brain structure. This study is among the first to examine the cross-sectional relat...

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Principais autores: Elizabeth R. Paitel, Corinne Pettigrew, Abhay Moghekar, Michael I. Miller, Andreia V. Faria, Marilyn Albert, Chan Hyun Na, Paul Worley, Anja Soldan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-06-01
Serier:Frontiers in Aging Neuroscience
Fag:
cognitive resilience
diffusion imaging
DTI
GluA4
NTPX2
synaptic
Online adgang:https://www.frontiersin.org/articles/10.3389/fnagi.2026.1851829/full
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