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Synthesis and Biological Evaluation of New Bis-Indolinone Derivatives Endowed with Cytotoxic Activity

A series of new Knoevenagel adducts, bearing two indolinone systems, has been synthesized and evaluated on 60 human cancer cell lines according to protocols available at the National Cancer Institute (Bethesda, MD, USA). Some derivatives proved to be potent antiproliferative agents, showing GI<sub>5...

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Principais autores: Rita Morigi, Elena Catanzaro, Alessandra Locatelli, Cinzia Calcabrini, Valentina Pellicioni, Alberto Leoni, Carmela Fimognari
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-10-01
Serier:Molecules
Fag:
programmed cell death
cell cycle
small molecules
indolinone systems
Knoevenagel reaction
Online adgang:https://www.mdpi.com/1420-3049/26/20/6277
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