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TAD boundaries and gene activity are uncoupled

Topologically associating domains (TADs) are prominent features of genome organization. A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD and by suppressing interactions between TADs. Here, we directly probe the structure-function relati...

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Bibliografische Detailangaben
Hauptverfasser: Faisal Almansour, Nadezda A Fursova, Adib Keikhosravi, Kathleen S Metz Reed, Daniel R Larson, Gianluca Pegoraro, Tom Misteli
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications Ltd 2026-04-01
Schriftenreihe:eLife
Schlagworte:
Online-Zugang:https://elifesciences.org/articles/110197
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