Transforming growth factor beta (TGF-β) induces type 1 interferon signalling in systemic sclerosis keratinocytes through the chloride intracellular channel 4 (CLIC4)

Abstract Objectives Systemic sclerosis (SSc) is an autoimmune disease, which is characterized by fibrosis of the skin, progressing to affect the internal organs in the most serve cases. Type 1 interferon (IFN) signalling plays a major role in SSc disease progression. The cytokine TGF-β has been exte...

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Prif Awduron:	Christopher W. Wasson, Sophie L. Dibb, Begoña Caballero-Ruiz, Ifeoluwa E. Bamigbola, Stefano Di Donato, Eva M. Madourie-Clavane, Rebecca Wells, Vishal Kakkar, Enrico De Lorenzis, Jessica Bryon, Emma Derrett-Smith, Christopher P. Denton, Yasser El-Sherbiny, Paul J. Meakin, Rebecca L. Ross, Francesco Del Galdo
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2025-09-01
Cyfres:	Arthritis Research & Therapy
Pynciau:	Scleroderma Interferon CLIC4 STAT1
Mynediad Ar-lein:	https://doi.org/10.1186/s13075-025-03632-6
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