TGF-β pathway activation by idiopathic pulmonary fibrosis (IPF) fibroblast derived soluble factors is mediated by IL-6 trans-signaling

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease characterized by a progressive decline in lung function. Fibrotic diseases, such as IPF, are characterized by uncontrolled activation of fibroblasts. Since the microenvironment is known to affect cell b...

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Bibliografski detalji

Glavni autori:	Gali Epstein Shochet, Elizabetha Brook, Becky Bardenstein-Wald, David Shitrit
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2020-02-01
Serija:	Respiratory Research
Teme:	IL-6 Fibroblasts STAT3 Fibrosis Tocilizumab sIL-6R
Online pristup:	http://link.springer.com/article/10.1186/s12931-020-1319-0
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