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Synergy between CD40 and MyD88 does not influence host survival to Salmonella infection

Previous studies using purified TLR ligands plus agonistic anti-CD40 antibodies showed that TLRs and CD40 can act synergistically on dendritic cells (DCs) to optimize T cell activation and Th1 differentiation. However, a synergistic effect of TLRs and CD40 during bacterial infection is not known. He...

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Principais autores: Ulf Alexander Wenzel, Maria eFernandez-Santoscoy, Miguel A. Tam, Pia eTegtmeyer, Mary Jo eWick
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015-09-01
coleção:Frontiers in Immunology
Assuntos:
Salmonella
dendritic cell
MyD88
CD40
NFκB
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00460/full
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