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Comparison of efficacy and safety between long-acting growth hormone and short-acting growth hormone in isolated growth hormone deficiency: a systematic review and meta-analysis of 16 randomized controlled trials involving 2,435 pediatric patients

ObjectiveTo comprehensively compare the efficacy and safety of long-acting human growth hormone (LAGH) preparations with conventional short-acting daily growth hormone (SA-GH) in children with isolated growth hormone deficiency (GHD), and explore potential differences across four distinct LAGH platf...

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Principais autores: Zhen-Zhen Shen, Yun Huang, Li-Li Wu, Jian-Su Zhang, Xiao-Xia Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-06-01
Serier:Frontiers in Pediatrics
Fag:
growth hormone deficiency (GHD)
long-acting human growth hormone
meta-analysis
randomized controlled trials
short-acting daily growth hormone
Online adgang:https://www.frontiersin.org/articles/10.3389/fped.2026.1776186/full
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