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Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer

Mechanistic/mammalian target of rapamycin (mTOR) has emerged as a new potential therapeutic target for gastric cancer. Rapamycin and rapamycin analogs are undergoing clinical trials and have produced clinical responses in a subgroup of cancer patients. However, monotherapy with rapamycin at safe dos...

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Principais autores: Weiqian Chen, Peng Zou, Zhongwei Zhao, Xi Chen, Xiaoxi Fan, Rajamanickam Vinothkumar, Ri Cui, Fazong Wu, Qianqian Zhang, Guang Liang, Jiansong Ji
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016-12-01
coleção:Redox Biology
Assuntos:
Gastric cancer
Rapamycin
EF24
Oxidative stress
Cytotoxicity
Antitumor
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213231716301331
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