Mechanistic insight into anaphase bridge signaling to the abscission checkpoint

Abstract During cytokinesis in human cells, a failure to resolve persistent DNA bridges that span the cell-division plane maintains the Aurora B-dependent abscission checkpoint in an active state. However, the molecular mechanism by which unresolved sister-chromatid bridging signals to this checkpoi...

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Autores principales:	Manika I Singh, Girish Rajendraprasad, Vasileios Katopodis, Rui Cui, Marin Barisic, Rahul Bhowmick, Ian D Hickson
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Springer Nature 2025-05-01
Colección:	The EMBO Journal
Materias:	ATR-CHK1 Signaling Chromosome Missegregation Aneuploidy Cytokinesis Failure Anchorage Independent Growth
Acceso en línea:	https://doi.org/10.1038/s44318-025-00453-w
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