Lactate Dehydrogenase A Depletion Alters MyC-CaP Tumor Metabolism, Microenvironment, and CAR T Cell Therapy

To enhance human prostate-specific membrane antigen (hPSMA)-specific chimeric antigen receptor (CAR) T cell therapy in a hPSMA+ MyC-CaP tumor model, we studied and imaged the effect of lactate dehydrogenase A (LDH-A) depletion on the tumor microenvironment (TME) and tumor progression. Effective LDH-...

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Detalles Bibliográficos

Principais autores:	Mayuresh M. Mane, Ivan J. Cohen, Ellen Ackerstaff, Khalid Shalaby, Jenny N. Ijoma, Myat Ko, Masatomo Maeda, Avi S. Albeg, Kiranmayi Vemuri, Jaya Satagopan, Anna Moroz, Juan Zurita, Larissa Shenker, Masahiro Shindo, Tanner Nickles, Ekaterina Nikolov, Maxim A. Moroz, Jason A. Koutcher, Inna Serganova, Vladimir Ponomarev, Ronald G. Blasberg
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2020-09-01
Series:	Molecular Therapy: Oncolytics
Assuntos:	lactate dehydrogenase A LDH-A lactate human prostate-specific membrane antigen hPSMA bioluminescence imaging
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2372770520301108
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