Engineering NKG2D ligand affinity transforms EGFR-targeted NK cell engagers into high-potency effectors against pancreatic cancer

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) often escapes T cell–mediated immunity through impaired major histocompatibility complex class I (MHC-I) antigen presentation, contributing to its limited responsiveness to T cell–based immunotherapies. Because natural killer (NK) cells are...

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Bibliografische Detailangaben

Hauptverfasser:	Seul-Gi Lee, Myungjee Lee, Hye-Min Lee, Ga-Hyun Son, Sang-Rok Yoon, Byeong-Ho Chae, Dae-Seong Kim, Kyung-Mi Lee, Yong-Sung Kim
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-03-01
Schriftenreihe:	Journal of Biological Engineering
Schlagworte:	αEGFR×NKG2DL immune cell engager (ICE) NKG2D ULBP6 affinity improvement Natural killer cells Pancreatic ductal adenocarcinoma (PDAC)
Online-Zugang:	https://doi.org/10.1186/s13036-026-00651-y
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