Sesquiterpene Lactones with Dual Inhibitory Activity against the <i>Trypanosoma brucei</i> Pteridine Reductase 1 and Dihydrofolate Reductase

The parasite <i>Trypanosoma brucei</i> (<i>T</i>. <i>brucei</i>) is responsible for human African trypanosomiasis (HAT) and the cattle disease “Nagana” which to this day cause severe medical and socio-economic issues for the affected areas in Africa. So far, most of the available treatment options a...

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Главные авторы:	Katharina Possart, Fabian C. Herrmann, Joachim Jose, Maria P. Costi, Thomas J. Schmidt
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2021-12-01
Серии:	Molecules
Предметы:	<i>Trypanosoma brucei</i> human African trypanosomiasis pteridine reductase 1 inhibitor dihydrofolate reductase inhibitor sesquiterpene lactones natural products
Online-ссылка:	https://www.mdpi.com/1420-3049/27/1/149
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