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PPAR-γ Activation Inhibits Angiogenesis by Blocking ELR+CXC Chemokine Production in Non-small Cell Lung Cancer

Activation of peroxisome proliferator-activated receptor-γ (PPAR-γ) results in inhibition of tumor growth in various types of cancers, but the mechanism(s) by which PPAR-γ induces growth arrest has not been completely defined. In a recent study, we demonstrated that treatment of A549 (human non smal...

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Principais autores: Venkateshwar G. Keshamouni, Douglas A. Arenberg, Raju C. Reddy, Michael J. Newstead, Shalini Anthwal, Theodore J. Standiford
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2005-03-01
Serier:Neoplasia: An International Journal for Oncology Research
Fag:
PPAR-γ
NSCLC
angiogenesis
CXC chemokines
NF-ΚB
Online adgang:http://www.sciencedirect.com/science/article/pii/S1476558605800302
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