Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer’s disease

Previous studies demonstrated that the PKR (double-stranded RNA-activated protein kinase) pathway was activated while the mTOR (mammalian target of rapamycin) pathway was inhibited in Alzheimer’s disease (AD). Here, we analysed upstream and downstream factors of mTOR in brain of APPSL/PS1 KI mice di...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Milena Damjanac, Agnès Rioux Bilan, Marc Paccalin, Raymond Pontcharraud, Bernard Fauconneau, Jacques Hugon, Guylène Page
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Elsevier 2008-02-01
श्रृंखला:	Neurobiology of Disease
विषय:	mTOR Akt/PKB p70/85S6K Alzheimer’s disease Translation Mouse transgenic model
ऑनलाइन पहुंच:	http://www.sciencedirect.com/science/article/pii/S0969996107002240
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