Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment

Abstract Background Extracellular vesicles (EVs) are nano-sized particles present in most body fluids including cerebrospinal fluid (CSF). Little is known about CSF EV proteins in HIV+ individuals. Here, we characterize the CSF EV proteome in HIV+ subjects and its relationship to neuroinflammation,...

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Hlavní autoři:	Debjani Guha, David R. Lorenz, Vikas Misra, Sukrutha Chettimada, Susan Morgello, Dana Gabuzda
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2019-12-01
Edice:	Journal of Neuroinflammation
Témata:	HIV Cognitive impairment CSF Extracellular vesicles Proteomics
On-line přístup:	https://doi.org/10.1186/s12974-019-1617-y
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