Interleukin-9 protects from microglia- and TNF-mediated synaptotoxicity in experimental multiple sclerosis

Abstract Background Multiple sclerosis (MS) is a progressive neurodegenerative disease of the central nervous system characterized by inflammation-driven synaptic abnormalities. Interleukin-9 (IL-9) is emerging as a pleiotropic cytokine involved in MS pathophysiology. Methods Through biochemical, im...

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Autori principali:	Livia Guadalupi, Valentina Vanni, Sara Balletta, Silvia Caioli, Francesca De Vito, Diego Fresegna, Krizia Sanna, Monica Nencini, Gloria Donninelli, Elisabetta Volpe, Fabrizio Mariani, Luca Battistini, Mario Stampanoni Bassi, Luana Gilio, Antonio Bruno, Ettore Dolcetti, Fabio Buttari, Georgia Mandolesi, Diego Centonze, Alessandra Musella
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-05-01
Serie:	Journal of Neuroinflammation
Soggetti:	Experimental multiple sclerosis Neuroinflammation Synaptopathy Microglia activation Inflammatory cytokines Glutamate transmission
Accesso online:	https://doi.org/10.1186/s12974-024-03120-9
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