Extracellular vesicle-derived miRNA-182-5p educates macrophages towards an immunosuppressive phenotype in pancreatic cancer

Abstract Reprogramming the immunosuppressive milieu in pancreatic cancer (PaCa) remains an important yet unmet therapeutic goal. Although tumor-associated macrophages (TAMs) are known to promote tumor growth and metastasis, little is known about the underlying mechanisms driving macrophage plasticit...

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Detalhes bibliográficos

Principais autores:	Baldev Singh, Pankaj Gaur, Pritha Bose, Yanjun Zhang, Yaoxiang Li, Zihao Zhang, Jeyalakshmi Kandhavelu, William Klotzbier, Meth Jayatilake, Shivani Bansal, Mohd Farhan, Sunain Deol, Partha P. Banerjee, Keith Unger, Seema Gupta, Vivek Verma, Amrita K. Cheema
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2026-01-01
coleção:	Signal Transduction and Targeted Therapy
Acesso em linha:	https://doi.org/10.1038/s41392-025-02559-3
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