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High Expression of the Costimulatory Checkpoint Factor DNAM-1 by CD4+ T-Cells from Multiple Myeloma Patients Refractory to Daratumumab-Containing Regimens

Abstract Multiple myeloma is an incurable disease characterized by unregulated growth of malignant plasma cells in the bone marrow (BM). Tumor-induced dysfunction of T-cells may be responsible for immune evasion and failure of immunotherapy. Therefore, a better understanding of the phenotype of T-ce...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Katrine Fladeland Iversen, Line Nederby, Thomas Lund, Torben Plesner
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAABRON PRESS 2022-08-01
Schriftenreihe:Clinical Hematology International
Schlagworte:
Multiple myeloma
Bone marrow microenvironment
Treatment
Immunotherapy
Daratumumab
Checkpoint inhibitor
Online-Zugang:https://doi.org/10.1007/s44228-022-00013-7
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