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In silico screening, synthesis, and biological evaluation of pyrazolopyrimidine-derived mTOR inhibitors for anticancer and senomorphic effects

Abstract Background Cellular senescence is a stress-induced state characterized by irreversible cell cycle arrest. Senescent cells accumulate during aging and contribute to age-related diseases, including neurodegeneration, cancer, and type 2 diabetes mellitus. The mTOR signaling pathway plays a cri...

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Main Authors: David Rysanek, Zofia Chrienova, Dorota Stary, Marek Bajda, Josef Novak, Pavla Vasicova, Jirina Kroupova, Rudolf Andrys, Adam Skarka, Erika Rousarova, Jan Capek, Tomas Rousar, Zoran Milovanovic, Jelica Grujic-Milanovic, Vesna Jacevic, Jayaprakash N. Kolla, Martin Popr, Dominika Maurencova, Patrik Oleksak, Lukas Fresser, Kamil Kuca, Zdenek Hodny, Eugenie Nepovimova
Format: Artigo
Language:Inglês
Published: BMC 2026-05-01
Series:Cancer Cell International
Subjects:
mTOR
Cellular senescence
Cell migration
Aging
Cancer
Torkinib
Online Access:https://doi.org/10.1186/s12935-026-04308-0
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