Suicide gene therapy targeting ewing sarcoma via an ewing-specific GGAA promoter
Abstract We recently demonstrated that GGAA promoters (GGAAprom) can be used to drive the expression of therapeutic genes (i.e., Cas9) in vitro and in vivo in a highly specific way in Ewing sarcoma cells. In this study, we take advantage of this strategy to express the suicide gene thymidine kinase...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
| Acceso en liña: | https://doi.org/10.1038/s41598-025-14945-6 |
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