An oxygen-generating nanoplatform remodels the immunosuppressive tumor microenvironment via synergistic lactate depletion and sonodynamic therapy

Abstract Lactate is an immunosuppressive molecule that plays an important role in tumor progression. Regulating lactate metabolism to remodel the immunosuppressive microenvironment represents a promising strategy for cancer therapy. However, owing to the hypoxic nature of the tumor microenvironment...

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Detalhes bibliográficos

Principais autores:	Chenchen Tang, Xinyi Tang, Jingwei Tang, Jie Hu, Li Wan, Jimei Chen, Ruqian Fu, Yang Cao, Rui Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-06-01
coleção:	Journal of Nanobiotechnology
Assuntos:	Immunosuppressive tumor microenvironment Lactate Sonodynamic therapy Immunogenic cell death
Acesso em linha:	https://doi.org/10.1186/s12951-025-03524-6
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