Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice.
Mutated NLRP3 assembles a hyperactive inflammasome, which causes excessive secretion of interleukin (IL)-1β and IL-18 and, ultimately, a spectrum of autoinflammatory disorders known as cryopyrinopathies of which neonatal-onset multisystem inflammatory disease (NOMID) is the most severe phenotype. NO...
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| Główni autorzy: | , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Public Library of Science (PLoS)
2018-11-01
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| Seria: | PLoS Biology |
| Dostęp online: | https://doi.org/10.1371/journal.pbio.3000047 |
| Etykiety: |
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