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Efficient and Safe Editing of Porcine Endogenous Retrovirus Genomes by Multiple-Site Base-Editing Editor

Gene-modified miniature pigs serve as alternative tissue and organ donors for xenotransplantation to alleviate the shortage of human allogenic organs. However, the high copy number of porcine endogenous retrovirus (PERV) genomes integrates with the porcine genome, which has a potential risk of cross...

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Збережено в:
Автори: Shuwen Zheng, Haiwen Zhong, Xiaoqing Zhou, Min Chen, Wansheng Li, Yin Zi, Yue Chi, Jinling Wang, Wei Zheng, Qingjian Zou, Liangxue Lai, Chengcheng Tang
Формат: Artigo
Мова:Inglês
Опубліковано: MDPI AG 2022-12-01
Серія:Cells
Предмети:
porcine endogenous retroviruses
base editors
multiple loci
Онлайн доступ:https://www.mdpi.com/2073-4409/11/24/3975
Теги: Додати тег
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