Hedgehog pathway activity downstream of Smoothened is regulated specifically by basal ciliary PKA

Abstract Background Effectors of the vertebrate Hedgehog (HH) signaling pathway are organized within primary cilia (PC). Protein kinase A (PKA), a ubiquitously distributed kinase in most cells, functions as a specific negative regulator of the HH pathway. Its functional specificity in the HH pathway...

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Autori principali:	Hongyu Zhang, Shujing Chen, Zhuoya Huang, Jin Ben, Yanling Wei, Guangxin Chen, Changxin Wu, Haibo Xie, Philip W. Ingham, Zhonghua Zhao
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-04-01
Serie:	Cellular & Molecular Biology Letters
Soggetti:	HH pathway Primary cilia Cilia targeted PKA Nphp3N-AKAR2 Smoothened
Accesso online:	https://doi.org/10.1186/s11658-026-00915-x
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