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Reperfusion injury in STEMI: a double-edged sword

Abstract Background ST-elevation myocardial infarction (STEMI) is a major cardiac event that requires rapid reperfusion therapy. The same reperfusion mechanism that minimizes infarct size and mortality may paradoxically exacerbate further cardiac damage—a condition known as reperfusion injury. Oxida...

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Principais autores: Krupa Sara Thomas, Divina Mariya Puthooran, Sudeep Edpuganti, Adi Lakshmi Reddem, Angela Jose, Subramanya Sri Mahesh Akula
Format: Artigo
Sprog:Inglês
Udgivet: SpringerOpen 2025-09-01
Serier:The Egyptian Heart Journal
Fag:
STEMI
Reperfusion injury
Primary percutaneous coronary intervention (PPCI)
Oxidative stress
Mitochondrial dysfunction
No-reflow phenomenon
Online adgang:https://doi.org/10.1186/s43044-025-00683-7
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