Rapamycin Attenuated Zinc-Induced Tau Phosphorylation and Oxidative Stress in Rats: Involvement of Dual mTOR/p70S6K and Nrf2/HO-1 Pathways

Alzheimer’s disease is pathologically characterized by abnormal accumulation of amyloid-beta plaques, neurofibrillary tangles, oxidative stress, neuroinflammation, and neurodegeneration. Metal dysregulation, including excessive zinc released by presynaptic neurons, plays an important role in tau pat...

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Detalhes bibliográficos

Principais autores:	Chencen Lai, Zhuyi Chen, Yuanting Ding, Qian Chen, Songbai Su, Heng Liu, Ruiqing Ni, Zhi Tang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-02-01
Colecção:	Frontiers in Immunology
Assuntos:	animal model tau hyperphosphorylation mTOR/p70S6K pathway Nrf2/HO-1 (nuclear factor erythroid 2-related factor-2/heme oxygenase-1) oxidative stress rapamycin
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.782434/full
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