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Microglial Pruning: Relevance for Synaptic Dysfunction in Multiple Sclerosis and Related Experimental Models

Microglia, besides being able to react rapidly to a wide range of environmental changes, are also involved in shaping neuronal wiring. Indeed, they actively participate in the modulation of neuronal function by regulating the elimination (or “pruning”) of weaker synapses in both physiologic and path...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Maria Concetta Geloso, Nadia D’Ambrosi
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2021-03-01
Schriftenreihe:Cells
Schlagworte:
microglia
pruning
neurodegeneration
multiple sclerosis
experimental autoimmune encephalomyelitis (EAE)
synaptic loss
Online-Zugang:https://www.mdpi.com/2073-4409/10/3/686
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