Structural and biochemical analyses of an aminoglycoside 2′-N-acetyltransferase from Mycolicibacterium smegmatis

Abstract The expression of aminoglycoside-modifying enzymes represents a survival strategy of antibiotic-resistant bacteria. Aminoglycoside 2′-N-acetyltransferase [AAC(2′)] neutralizes aminoglycoside drugs by acetylation of their 2′ amino groups in an acetyl coenzyme A (CoA)-dependent manner. To und...

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Detalles Bibliográficos

Principais autores:	Chang-Sook Jeong, Jisub Hwang, Hackwon Do, Sun-Shin Cha, Tae-Jin Oh, Hak Jun Kim, Hyun Ho Park, Jun Hyuck Lee
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2020-12-01
Series:	Scientific Reports
Acceso en liña:	https://doi.org/10.1038/s41598-020-78699-z
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