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Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing

Aβ peptides, the major components of Alzheimer’s disease (AD) amyloid deposits, are released following sequential cleavages by secretases of its precursor named the amyloid precursor protein (APP). In addition to secretases, degradation pathways, in particular the endosomal/lysosomal and proteasomal...

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Principais autores: Caroline Evrard, Pascal Kienlen-Campard, Mathilde Coevoet, Rémi Opsomer, Bernadette Tasiaux, Patricia Melnyk, Jean-Noël Octave, Luc Buée, Nicolas Sergeant, Valérie Vingtdeux
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-11-01
Serier:Frontiers in Cellular Neuroscience
Fag:
Alzheimer’s disease
amyloid precursor protein
amyloid beta peptide
APP-CTF
C99
Online adgang:https://www.frontiersin.org/article/10.3389/fncel.2018.00435/full
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