RNAPII-dependent ATM signaling at collisions with replication forks
Abstract Deregulation of RNA Polymerase II (RNAPII) by oncogenic signaling leads to collisions of RNAPII with DNA synthesis machinery (transcription-replication conflicts, TRCs). TRCs can result in DNA damage and are thought to underlie genomic instability in tumor cells. Here we provide evidence th...
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| Principais autores: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2023-08-01
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| Serier: | Nature Communications |
| Online adgang: | https://doi.org/10.1038/s41467-023-40924-4 |
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