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Monotherapy with antibody 1C3 partially protects Ebola virus-exposed macaques

ABSTRACT A cocktail of human monoclonal antibodies 1C3 and 1C11 previously protected macaques from a lethal exposure to either Ebola virus (EBOV) or Sudan virus (SUDV). 1C3 is of particular interest because its paratope strongly binds with unique stoichiometry to the glycoprotein head of several ort...

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Autori principali: Gabriella Worwa, Carl W. Davis, Sarah E. Klim, Jacquelyn Turcinovic, Krystle N. Agans, Viktoriya Borisevich, Joan B. Geisbert, Robert W. Cross, Anya Crane, Michael R. Holbrook, Mariano Sanchez-Lockhart, Jeffrey R. Kugelman, Juan A. Patino Galindo, Thomas W. Geisbert, Rafi Ahmed, Jens H. Kuhn, Erica Ollmann Saphire, Gustavo Palacios, Ian Crozier
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2025-07-01
Serie:Journal of Virology
Soggetti:
1C3
1C11
Ebola virus
EBOV
escape mutation
glycoprotein
Accesso online:https://journals.asm.org/doi/10.1128/jvi.00296-25
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