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Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common lethal cancers worldwide. Natural killer cells (NK cells) play a key role in liver immunosurveillance, but in the tumor microenvironment, NK cells are readily depleted, as evidenced by down-regulation of activating receptors, reduced cytokine...

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Principais autores: Yuxiang Huang, Hengjian Liao, Jiefu Luo, Huaning Wei, Anling Li, Yujie Lu, Bangde Xiang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-01-01
coleção:Frontiers in Oncology
Assuntos:
hepatocellular carcinoma
NK cell exhaustion
immunotherapy
immune checkpoint blockade
drug sensitivity
tumor microenvironment
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2024.1502270/full
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