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Screening a library of temperature-sensitive mutants to identify secretion factors in Staphylococcus aureus

ABSTRACT Protein secretion is an essential cell process in bacteria, required for cell envelope biogenesis, export of virulence factors, and acquisition of nutrients, among other important functions. In the Sec secretion pathway, signal peptide-bearing precursors are recognized by the SecA ATPase an...

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Principais autores: Owen Leddy, Amany M. Ibrahim, Muhammad S. Azam, Sadie Solomon, Wenqi Yu, Olaf Schneewind, Dominique Missiakas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2025-02-01
Serier:Journal of Bacteriology
Fag:
Staphylococcus aureus
temperature-sensitive mutant
protein secretion
SecA
SecG
PepV
Online adgang:https://journals.asm.org/doi/10.1128/jb.00433-24
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