Affinity-matured CD72-targeting nanobody CAR T cells enhance elimination of antigen-low B-cell malignancies

Background Chimeric antigen receptor (CAR) T-cell therapies are highly efficacious for several different hematologic cancers. However, for most CAR T targets it is observed that low surface antigen density on tumors can significantly reduce therapeutic efficacy. In this study, we explore this dynami...

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Detalles Bibliográficos

Principais autores:	Amit Verma, Marcela V Maus, Nirali N Shah, Rebecca C Larson, Samir Parekh, Hao-Wei Wang, Christopher Carpenter, Emilio Ramos, William C Temple, Matthew A Nix, Akul Naik, Adila Izgutdina, Paul Phojanakong, Juan Antonio Camara Serrano, Fernando Salangsang, Veronica Steri, Arun P Wiita, Constance M Yuan, Tasfia Rashid, Sarah Aminov, Bonell Patiño-Escobar, Sujata Walunj, Huimin Geng, Hiroyuki Takamatsu, Daniel Gil-Alós, Amrik S Kang, Szu-Ying Chen, Haley Johnson, Mingcheng Li, Srabani Sahu, Isa Tariq, Ons Zakraoui, Antonio Valeri, Joaquin Martinez-Lopez
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMJ Publishing Group 2025-12-01
Series:	Journal for ImmunoTherapy of Cancer
Acceso en liña:	https://jitc.bmj.com/content/13/12/e012013.full
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