CD8⁺ T Cells Mediate Lethal Lung Pathology in the Absence of PD-L1 and Type I Interferon Signalling following LCMV Infection

CD8⁺ T cells are critical to the adaptive immune response against viral pathogens. However, overwhelming antigen exposure can result in their exhaustion, characterised by reduced effector function, failure to clear virus, and the upregulation of inhibitory receptors, including programmed...

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Detalhes bibliográficos

Principais autores:	Alanna G. Spiteri, Tamara Suprunenko, Erin Cutts, Andrew Suen, Thomas M. Ashhurst, Barney Viengkhou, Nicholas J. C. King, Markus J. Hofer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-03-01
coleção:	Viruses
Assuntos:	lymphocytic choriomeningitis virus (LCMV) T cell exhaustion lung pathology type 1 interferon IFNAR1 PD-L1
Acesso em linha:	https://www.mdpi.com/1999-4915/16/3/390
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