Exosomal SPRY4 from adipogenic BMSCs impairs angiogenesis via the PTPRB/TIE2/PI3K axis in Steroid-induced osteonecrosis of the femoral head

Abstract Background Steroid-induced osteonecrosis of the femoral head (SONFH) drives irreversible bone collapse, yet current therapies inadequately target the disrupted angiogenic-osteogenic coupling central to its pathogenesis. Although pathological adipocyte hyperplasia is a hallmark of SONFH, the...

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Autori principali:	Dulei Xiang, Yuandong Zhou, Hongwei Wang, Yu chen, Haobo Bai, Zihan Wang, Siyu Tan, Dong Wu, Wenlong Yan, Xiao Huang, Tingmei Chen, Chengjie Lian, Jian Zhang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-07-01
Serie:	Stem Cell Research & Therapy
Soggetti:	Steroid-induced osteonecrosis of the femoral head Exosomes Adipogenesis Angiogenesis SPRY4 PTPRB
Accesso online:	https://doi.org/10.1186/s13287-025-04505-0
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