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Occlusion of dopamine-dependent synaptic plasticity in the prefrontal cortex mediates the expression of depressive-like behavior and is modulated by ketamine

Abstract Unpredictable chronic mild stress (CMS) is among the most popular protocols used to induce depressive-like behaviors such as anhedonia in rats. Differences in CMS protocols often result in variable degree of vulnerability, and the mechanisms behind stress resilience are of great interest in...

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Bibliografische Detailangaben
Hauptverfasser: Jacopo Lamanna, Francesco Isotti, Mattia Ferro, Sara Spadini, Gabriella Racchetti, Laura Musazzi, Antonio Malgaroli
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2022-06-01
Schriftenreihe:Scientific Reports
Online-Zugang:https://doi.org/10.1038/s41598-022-14694-w
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