Multiple myeloma derived sulfur dioxide drives CAR-T cell exhaustion by inducing mitochondrial dysfunction

Metabolic disorders mediated chimeric antigen receptor - T cell (CAR-T) exhaustion impaired cancer immunotherapy. Endogenous sulfur dioxide (SO2) derived from L-cysteine catalysis regulated immune cell functions. However, its role in CAR-T cell exhaustion remained unknown. In this study, we identifi...

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Autors principals:	Zhengyu Yu, Hua Lin, Jingran He, Linfeng Li, Zhongwang Wang, Kun Li, Ting Niu, Bingquan Qiu
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2026-03-01
Col·lecció:	Redox Biology
Matèries:	CAR-T therapy Multiple myeloma CAR-T cell exhaustion Sulfur dioxide DRP1 Mitochondrial dynamics
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2213231726000388
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